The extended-spectrum beta-lactamases confer resistance to which antibiotic?

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Prepare for the Clinical Laboratory Science Microbiology Test with engaging content and multiple choice questions. Each question is accompanied by hints and detailed explanations to enhance your learning experience and boost your confidence for the examination!

Multiple Choice

The extended-spectrum beta-lactamases confer resistance to which antibiotic?

Explanation:
Extended-spectrum beta-lactamases inactivate beta-lactam antibiotics by breaking the beta-lactam ring. Ceftriaxone is a third-generation cephalosporin, a type of beta-lactam, so bacteria producing ESBLs are typically resistant to ceftriaxone. The other drugs listed are not beta-lactams (am I kin to amikacin is an aminoglycoside; erythromycin a macrolide; rifampin a rifamycin), so they are not inherently affected by ESBLs through this mechanism. In infections with ESBL producers, ceftriaxone would be ineffective, guiding clinicians toward alternative treatments such as carbapenems.

Extended-spectrum beta-lactamases inactivate beta-lactam antibiotics by breaking the beta-lactam ring. Ceftriaxone is a third-generation cephalosporin, a type of beta-lactam, so bacteria producing ESBLs are typically resistant to ceftriaxone. The other drugs listed are not beta-lactams (am I kin to amikacin is an aminoglycoside; erythromycin a macrolide; rifampin a rifamycin), so they are not inherently affected by ESBLs through this mechanism. In infections with ESBL producers, ceftriaxone would be ineffective, guiding clinicians toward alternative treatments such as carbapenems.

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